LY2409881 trihydrochloride
- Product Name
- LY2409881 trihydrochloride
- CAS No.
- 946518-60-1
- Chemical Name
- LY2409881 trihydrochloride
- Synonyms
- LY2409881;CS-1620;LY2409881 3HCl;LY-2409881 HC'l;LY2409881 triHCl;LY-2409881 ;LY 2409881;LY2409881 trihydrochloride;LY2409881 trihydrochloride USP/EP/BP;2-[5-chloro-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]-N-cyclopropyl-1-benzothiophene-4-carboxamide;LY2409881 trihydrochloride,Inhibitor,IκB kinase,Apoptosis,IKK,inhibit,I kappa B kinase,LY-2409881 trihydrochloride
- CBNumber
- CB42743099
- Molecular Formula
- C24H30Cl2N6OS
- Formula Weight
- 521.51
- MOL File
- 946518-60-1.mol
LY2409881 trihydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- ≥59.4 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
- form
- solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 18774
- Product name
- LY2409881
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18774
- Product name
- LY2409881
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 18774
- Product name
- LY2409881
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 18774
- Product name
- LY2409881
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $305
- Updated
- 2024/03/01
- Product number
- C370110
- Product name
- 2-[5-Chloro-2-[[3-(4-methylpiperazin-1-yl)propyl]amino]pyrimidin-4-yl]benzo[b]thiophene-4-carboxamideN-cyclopropylTrihydrochloride
- Packaging
- 2.5mg
- Price
- $120
- Updated
- 2021/12/16
LY2409881 trihydrochloride Chemical Properties,Usage,Production
Uses
2-[5-Chloro-2-[[3-(4-methylpiperazin-1-yl)propyl]amino]pyrimidin-4-yl]benzo[b]thiophene-4-carboxamide N-cyclopropyl Trihydrochloride is an inhibitor of IkB-kinase (IKK2). Small molecules that inhibits IkB-kinase and NF-κB pathways are potential anti-inflammatory drug candidate.
Biological Activity
ly2409881 is a potent and selective inhibitor of ikk2 with ic50 value of 30 nm [1].iκb kinase β (ikk2) is an enzyme that serves as a subunit of iκb kinase, which is involved in the cytokine-activated immune responses. ikk2 activates nuclear factor kappa-b kinase (nf-κb).ly2409881 is a selective ikk2 inhibitor and exhibited >10-fold selectivity over other common kinases and ikk1. in the ovarian cancer cell line skov3, ly2409881 showed moderate cytotoxicity. while coadministration of ly2409881 and tnfɑ significantly induced cells death, which suggested ly2409881 inhibited nf-κb mediated antiapoptotic signals in a tnfɑ-dependent way. in the dlbcl cell line ly10, ly2409881 (10 μm) inhibited tnfɑ-dependent phosphorylation of iκb. in the dlbcl cell line sudhl2, ly2409881 (10 μm) inhibited the nuclear signals of p50 and nf-κb. also, ly2409881 induced apoptosis in a concentration-dependent way [1].in scid-beige mice bearing ly10 cell-derived tumors, ly2409881 (50, 100 and 200 mg/kg) significantly inhibited tumor growth [1].
References
[1]. deng c, lipstein m, rodriguez r, et al. the novel ikk2 inhibitor ly2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of nf-κb. clin cancer res, 2015, 21(1): 134-145.
LY2409881 trihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
LY2409881 trihydrochloride Suppliers
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View Lastest Price from LY2409881 trihydrochloride manufacturers
- Product
- LY2409881 trihydrochloride 946518-60-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23